Obstacles in life are important..?

Every obstacle presents an opportunity to improve our condition.
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MS funding is declining!

For those of you in the US… please take a minute to read this and sign the petition to continue funding future R&D for MS. It is very important

Thank you

http://capwiz.com/nmss/issues/alert/?alertid=9167296&type=CU

Aimspro Info

What is Aimspro?

Aimspro is the trade name for an MS treatment produced from the serum of blood obtained from specially vaccinated goats. The serum is obtained from the goats in the USA and then sent to the UK for purifying.

Who makes Aimspro?

Daval International is a UK based pharmaceutical research and development company. Founded by venture capitalist David Shotton from London in 2000.

How is Aimspro administered?

Patients are taught to inject themselves with the drug in the upper arm, thighs or buttocks using a needle very like that used by diabetics.

How does Aimspro work?

Aimspro uses Polyclonal Antibodies from the serum of goats that have been inoculated with a number of vaccines to generate neutralising antibodies. The exact action is not fully understood and the technique is subject to commercial confidentiality.

Does Aimspro work?

The trials have been very positive with many patients reporting significant improvement. There have been very few reporting no improvement.

Are there any side-effects?

The only reported side-effects have been a slight irritation at the injection site.

Is Aimspro a cure for MS?

No, it is a treatment to lessen the symptoms of multiple sclerosis, including actual partial reversal of some symptoms leading to a better quality of life for many patients.

How can I obtain Aimspro?

Aimspro is not generally available as the drug has not yet been licensed. The product is currently undergoing Phase II trials and it is hopeful that the drug may be approved within the next year or two. In the meantime you can sign the petition being run by the Aimspro Patient Lobby Group, Proventus.

There is hope, however, Daval are now reported to be running ‘Specials‘ or Aimspro on named patient basis. Presumably this is available only in the UK.

Where can I get more information about Aimspro?

The Multiple Sclerosis Resource Centre publish a very good magazine, called New Pathways that has regular updates and news about Aimspro.

Are the goats harmed in the manufacture of Aimspro?

No, on the contrary, they are very well cared for. They live on a farm in the USA, are looked after by qualified carers, are certified free of any disease and have the freedom to roam around in large paddocks. Extracting the blood from the goats is very like people donating blood.

Aimspro – yet another Multiple Sclerosis treatment

Aimspro®

Aimspro shows great promise for the treatment of a range of neurological and inflammatory conditions including multiple sclerosis, CIDP and rheumatoid arthritis. Aimspro has been characterised biochemically and its mode of action has been determined. It comprises of a set of peptides that act to stimulate the release and regulation in the patient, of a molecular cascade that modulates the Hypothalamo-Pituitary-Adrenal (HPA) axis; a system found to be dysfunctional in some patients suffering from Multiple Sclerosis. In addition, Aimspro has powerful anti-inflammatory properties as it contains cytokines that induce a predominantly TH-2 anti-inflammatory profile in the patient thus relieving symptoms in a wide range of inflammatory conditions.

It has become apparent that some of the peptides in Aimspro are regulated and bound by specific carrier molecules that may regulate the action and release of their ligand and are probably necessary for the appropriate regulation and pharmacokinetics of the molecular machinery. The carrier molecules also function as a slow release mechanism, releasing bioactive components over several days.

Compared with conventional drugs, which generally comprise one molecule destined to interact with one target in the body, the unique molecular complexity of Aimspro enables it to interact with many molecular targets in concert, hence bringing about a wide range of physiological benefits.

MS problems & frustrations

I have been noticing that there is a general feeling among all of us MSers (or is it that I just noticed the ones I recognized myself with?:)

I, too, am not feeling as great. I believe my MS is getting worse…or am I just having an attack?

I have become a bit less social I think…hmm not sure if it is true. I know it is due to my MS. I have been having peeing problems (can’t empty my bladder fully and as soon as I step out of the house I need a toilet! which is a problem especially when there isn’t one around!). I noticed that when going out (if ever) this problem is even more serious especially if I drink beer (from now on – no more beer – it wasn’t something I liked to drink anyways! So…good;). I also noticed that I decline parties and other social events because I am tired or because I think I am not going to be able to walk (or I will…but it would be very tiring so why bother…). I feel that I have become an orange skin accumulator… basically I am simply at home most of the time, I do not exercise anymore (which I am not happy about at all…! I want to go back to doing some sports)… I am considering starting on yoga… and maybe aerobics again.

What else? I am also wondering about this MS… Where is it going? How long do we have to wait for a cure? The article I previously posted is really impressive… I know my MS hasn’t advanced yet (to the point where I can’t walk at all anymore or something like that) but I feel like I am getting tired of fighting it already… why?

Wow… I am really frustrated… REALLY. But on top of all this… I know I have to go on fighting it, and I will! I just wanted to say that it is OK if we feel down sometimes…it is all part of having MS…

I feel like I wanted to say something more…but now I forgot… Can’t wait to go see my doctor for the regular 6-month check-up…planning to have a nice chat with her to see what the progress of my MS is so far…and request an MRI scan.

Best to you all!

Heads up;)

New Multiple Sclerosis Treatment Reduces Relapse Rate By 90%

Article Date: 22 Jul 2006 – 14:00 PST

Multiple Sclerosis patients who receive a brief course of Mitoxantrone, and then Copaxone, experience a reduced replase rate of 90%, according to a five-year study carried out at The Walton Centre for Neurology, Liverpool, UK. A further ten controlled studies are being launched at 10 centres in the UK. A reduced relapse rate of 90% means the difference between being bedridden and holding down a job and actively raising a family for many MS patients. You can read about this study in the Journal of Neurology, August issue. Mitoxantrone is used for treating cancer patients, it is so powerful that it can only be used for a short time. Copaxone is a slow-acting disease-moderating drug for MS patients. In this study, doctors decided to overlap the treatments because they wanted to give some time for copaxone to build up its effect. Head researcher, Dr Mike Boggild, said “This regime has proved remarkably effective. Though there are certain risks, associated particularly with use of Mitoxantrone, we have been able to limit these by using this agent for just a short induction period. Balanced against the high risk of early disability for these patients, the outcomes appear to justify this approach.” Dr. Boggild started treating with Karen Ayres, 28, in 2002. Karen Ayres has MS. Since 2002 she has not suffered any relapses at all. Ayres said she came to see Dr. Boggild during her second relapse. She was unable to walk or feed herself – she was barely able to wave her hand. A few weeks after treatment started she walked out of the rehab centre unaided. She says that since the beginning of this treatment she has managed to lead a completely normal life – she has travelled to five continents and is currently doing a PhD in Psychology at Leeds University, UK. Ayres was one of 27 patients treated during this open trial. Many of them experienced similar remarkable reductions in relapses. This study was not a controlled one. This means there was not one group of patients on the drug treatment compared to another group on a placebo. The ten new studies are controlled ones. The treatment does have potentially serious side-effects, including leukaemia and cardiac problems. However, for many MS patients, it is still worth the risk.

Journal of Neurology

Written by: Christian Nordqvist

Editor: Medical News Today 

Some people I know say the cure for MS is somewhere near…Hope they are right.

Is MS Fatal?

wow…I found this just now when surfing… shocker.

As a group, people with MS have a life expectancy estimated at 6-7 years less than the general population. The vast majority of people with MS die from the same diseases as everyone else–heart disease, cancer, or stroke.

Death caused directly by an MS lesion is extremely unusual. Without adequate medical care, it might result from a lesion in the part of the brain that regulates breathing or from large areas of demyelination that interfere with life-supporting systems in the body. Certain complications of advanced MS, such as severe urinary tract infections, pneumonia, or extensive skin breakdown, can also threaten life and may prove fatal even with adequate treatment. Modern antibiotic therapy and sophisticated supportive care strategies make it possible to control these problems in most cases. Severe untreated depression is also known to be responsible for the relatively high suicide rate among people with MS. The Society is committed to educating our community about the importance of identifying and treating MS-related depression.

The contradiction is apparent but not real: severe MS or its complications may be fatal, but the likelihood is so rare that MS cannot be considered a fatal disease.

COPYRIGHT 2002 National Multiple Sclerosis Society
COPYRIGHT 2002 Gale Group

Contradicting? Yeah..but still scary! :p

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