Hughes Syndrome: The blood disease that mimics Multiple Sclerosis!!

Could you have been wrongly diagnosed???
By Judy Graham

Up to 5% of those diagnosed with Multiple Sclerosis don’t have the disease at all. They have something called Hughes Syndrome, a hidden blood disease which in some ways mimics MS. It is also known as “Sticky Blood Syndrome”.

Instead of having MS, some patients could be suffering from this relatively new disease which mimics some symptoms of MS.

Like MS, Hughes Syndrome can affect mobility, memory, the speech and the nervous system. But the differences. Hughes Syndrome is easy and cheap to treat…

Source: http://www.msrc.co.uk/index.cfm?fuseaction=show&pageid=736

For more info on Hughes syndrome (APS) go to: http://www.hughes-syndrome.org/

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Pregnancy & Multiple Sclerosis

A Canadian research suggests that a pregnancy hormone may help repair the damage to nerves caused by multiple sclerosis.

The Journal of Neuroscience study, by the University of Calgary, may explain why MS tends to go into remission while women are pregnant.

Working on mice, the researchers found the hormone – prolactin – encourages production of myelin, the fatty substance that protects nerve cells. When mice with MS-like nerve damage were injected with the hormone, their myelin was also repaired.

From today’s news (http://news.bbc.co.uk/2/hi/health/6376257.stm)

‘Benign’ MS May Not Be So Benign

Also from Medical News Today…dated today..

People who have multiple sclerosis (MS) for 10 years and have few of the disabling symptoms of the disease are often told they have “benign MS” and that their symptoms will likely not ever occur to the same extent as other people with MS. A new study, published in the February 13, 2007, issue of Neurology®, the scientific journal of the American Academy of Neurology, shows that unfortunately this may not be correct.

After 20 years, the disease had progressed in nearly half of those whose MS was benign at 10 years, according to the study.

The study of 169 people whose MS was benign after 10 years found that after 20 years the disease had progressed in 21 percent to the extent that they needed a cane to walk. Most of the patients had the relapsing-remitting form of the disease, where symptoms come and go. But after 20 years, about 20 percent of the people had developed the secondary-progressive form of the disease, where the disease steadily progresses.

“We need to be careful what we tell people, and not give them false hope that their symptoms may never get worse,” said lead study author Ana-Luiza Sayao, MD, of the University of British Columbia in Vancouver, Canada.

And unfortunately as always with MS… no factors have been found common among the people tested (gender, age…) but “more research needs to be done to identify criteria to determine which people will remain with mild disability over the long term.”

Brain Atrophy & Multiple Sclerosis

February 15th, Medical News Today…

In patients with recently diagnosed multiple sclerosis, the extent of accumulated brain tissue loss and overall lesion load as determined by magnetic resonance imaging (MRI) may predict the rate of cerebral atrophy over the following two years, according to a report in the Archives of Neurology, one of the JAMA/Archives journals.

It has been almost two years since I was diagnosed…but I will not qualify for an MRI scan until end of 2008… I recently asked my doctor to do an MRI scan but she gave me this reply. Would have liked it now…instead of next year…:p

The BIG Idea: Veins the “key” to discover the origins of Multiple Sclerosis?

In very very brief:

The Big Idea: Iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis. This was a study conducted by Paolo Zamboni and is found under http://www.jrsm.org/cgi/content/full/99/11/589 for purchase (in English). His research is yet to be studied and confirmed but it is an interesting perspective on the disease. Here is a brief outline in Italian from an Italian newspaper 2-3 weeks ago.

Nelle vene la «chiave» per scoprire l’ origine della sclerosi multipla

The Big Idea: quando sulla prestigiosa rivista della Royal Society of Medicine è comparsa la sua ricerca, l’ hanno titolata così, prima di una serie dedicata alle «grandi idee» per il futuro della medicina. In questo caso, ad entrare in gioco è lo studio sulla sclerosi multipla: perché secondo Paolo Zamboni, chirurgo vascolare e docente all’ ateneo di Ferrara, la chiave dell’ enigma potrebbe celarsi in un luogo inaspettato – le vene. Strana idea davvero, quella di collegare una malattia del tessuto cerebrale alle infiammazioni vascolari; soprattutto se ad avanzare l’ipotesi non è un esperto di sclerosi multipla, «mi ci sono avvicinato 5 anni fa, dopo la malattia di una persona cara. Ho divorato tutti i testi disponibili, dai primi studi di Jean-Martin Charcot al diario di Augusto d’ Este, nipote di Giorgio d’ Inghilterra». Conclusione: dall’ 800 ad oggi, nulla – o quasi – è cambiato per i malati. L’ origine della causa più comune di disabilità tra i giovani (le prime crisi si manifestano tra i 20 e i 30 anni), che colpisce e annienta il tessuto cerebrale con focolai di infiammazione, resta ignota. «Ma un particolare mi colpiva: nel 99% dei casi le placche della sclerosi “seguono” le vene del cervello o del midollo spinale». Nel corso delle sue ricerche sulle infiammazioni vascolari, Zamboni nota che «quando la circolazione nelle vene non funziona bene, come nelle varici, le gambe hanno macchie scure: depositi di ferro, pericolosi in quanto fonte di radicali liberi. E anche nelle placche della sclerosi, guarda caso, c’ è molto più ferro che nei tessuti normali». Il che potrebbe spiegarsi con un’ irregolarità nella circolazione, un’ ipotesi affascinante da provare a testare. «Sappiamo che nella placca passa una vena, sappiamo che c’ è un accumulo di ferro: resta da capire se questa vena funziona bene o male». E questo non lo può svelare né la Tac, né la risonanza magnetica. A Ferrara, neurologi e chirurghi vascolari stanno già studiando un metodo per l’ analisi emodinamica delle vene cerebrali; al fianco di Zamboni, un team di 15 persone – medici, ricercatori, specializzandi – che alla big idea dedica, come lui, ogni minuto libero e una buona dose di entusiasmo. La nuova «finestra» sulla sclerosi multipla è ormai spalancata.