CCSVI discovery — a brief story of its background

One cannot ignore the fact that the research surrounding CCSVI and its benefits for patients with MS has received a lot of attention lately (prof. Zamboni’s research). So it came to my mind that I forgot to mention the reaction of my doctor at the news when I told her about this new discovery…”oh..but thats not news”.

I thought it would be interesting to bring this up as it relates to the ‘new’ discovery… Namely, along with my doctor’s “oh but thats not news” she added that in 1965 a Danish professor – Torben Fog – described the MS pathology in his thesis “so it is well known from that time that MS lesions are predominantly around the small veins (venoles)” she added. Her remarks increased my curiosity and thus I researched a bit more on what exactly did Professor Fog discover back in the Sixties. I came across a few things…I thought I’d share with you. To me it is shocking…in many ways…as it dates back to the 60s…

Fog reviewed the literature on the relationship of the vessels to plaques from Rindfleisch’s observations in 1863 to 1947. Noting the theory of Putnam (1930-1939) that thrombosis of small veins may be the underlying mechanism of plaque formation, and the studies on this by Dow and Berglund (1942), Zimmermann and Netsky (1950), and his own work (1948, 1959), Fog concluded that there may be some small vessel changes, but these are intermitted and variable. His subsequent study of 51 plaques from two cases of typical MS, making thin sections of the plaques and following their shape and course with direct drawings of each section, showed that most (39/51) were prolongations of periventricular plaques, and that the plaques did follow the course of the venous system. (Ref: T. Jock Murray, 2005, Multiple sclerosis: the history of a disease)

Fog on the Vein-Conditioned Plaque Development – quoted here just briefly as, I believe, it is a complex and maybe somewhat difficult to grasp article, which is also why I leave a reference in the end for those interested in reading the whole article – In 1965 Torben Fog, directly investigating the multiple sclerosis-specific cerebral lesions’ relationship to the course of their veins, found the distinctive plaques to consistently develop in a peculiar dependence upon definite vein segments. (Ref: Fog Torben, The topography of plaques in multiple sclerosis, with special reference to cerebral plaques. Acta Neurol Scand, 41,Suppl. 15:1, 1965)

For other references on Fog’s research see: Fog T. On the vessel-plaque relations in the brain in multiple sclerosis. Acta Psychiat Neurol Scand. 1963; 39, suppl. 4:258

To see my previous entry on this topic:


5 Comments (+add yours?)

  1. Trackback: Preliminary CCSVI Results Announced! « Multiple Sclerosis & Life
  2. Trackback: CCSVI – yet another article « Multiple Sclerosis & Life
  3. Trackback: A CCSVI success story… « Multiple Sclerosis & Life
  4. Trackback: MS: an in-depth view « Multiple Sclerosis & Life
  5. Trackback: CCSVI in MS – new findings in the field!! « Multiple Sclerosis & Life

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