Living in a “cleaner society” might have caused your MS?

Medical News Today (July 20th 2010):

Scientists seem to have discovered a link between gut bacteria and MS.

They claim that microorganisms seem to play some role in the cause of MS, which remains still unknown. The researchers started from the following proposition and based on literature on bacteria & MS:

“As we live cleaner, we’re not just changing our exposure to infectious agents, but we’re changing our relationship with the entire microbial world, both around and inside us, and we may be altering the balance between pro- and anti-inflammatory bacteria,” leading to diseases like MS, Mazmanian says.

As they gained an appreciation for how profoundly the gut microbiota can affect the immune system, they then decided to question if symbiotic bacteria are the missing variable in the mice with MS they were researching on. They claim that there is a clear connection between gut microbes and MS, and that dysbiosis (the dysregulation of normal gut bacterial populations) may be the explanation for the rising rate of MS seen in recent years in more hygienic societies. (!)

“Bacteria will kill you” huh? hmmm…maybe it was better for us MSers to be “dirtier”/unhygienic…? wonder what happens if we start now.. be unhygienic… find it difficult to believe as it is exactly what my nurse discouraged…”be as hygienic as possible sweetie, you don’t want something extra to get you”, she said. Oh well, I guess we’ll have to wait and see what they find out from further research.

Protein able to abolish recurring relapses in MS…

From Medical News Today (article dated: 07.07.2010)

Compugen Ltd. announced that (in an animal model of MS) a protein has shown to be able to completely abolish recurring relapses in MS.

In fact, CGEN-15001 has also demonstrated that its administration prior to disease onset delays disease onset and significantly decreases disease symptoms.

The results of this study and those of earlier studies, strongly support the significant potential therapeutic use of CGEN-15001 for the treatment of MS, as well as other autoimmune diseases.

Cancer drug & MS

An article published July 2nd, on the Medical News Today website reports on yet another cancer drug that shows promise for the treatment of a wide range of inflammatory diseases, among them MS:

Those looking for a new treatment for a range of inflammatory diseases like arthritis, multiple sclerosis, inflammatory bowel disease, and lupus may need to look no further than a drug already available for treating cancer.

In fact, Japanese scientists used mice to show that bortezomib, which is currently used to treat cancers that affect white blood cells, induces cell death only in harmful T cells (active and proliferating ones), thus leaving the rest unharmed. What is interesting about bortezomib, proven its efficiency on humans, is that it would not have the side effects that current drugs have (which affect all T cells equally).

CCSVI clinical trials to start!

It has been almost a year since CCSVI was first mentioned…and it has now been finally announced that clinical trials will start . On July 1st Medical News Today announced that:

Buffalo medical researchers led by a team from the University at Buffalo Department of Neurosurgery, will embark on a landmark prospective randomized double-blinded study to test the safety and efficacy of interventional endovascular therapy – dubbed “liberation treatment” – on the symptoms and progression of Multiple Sclerosis (MS).

This is the news we’ve all been waiting to hear – hopefully clinical trials will determine if CCSVI intervention is helpful for the treatment of MS and open the possibility for people around the world to undergo this treatment.