Key Biological Mechanism In MS possibly identified!

from the article, a very interesting discovery:

Fibrinogen, a blood protein that is involved in coagulation, is not found in the healthy brain. In vivo imaging over different stages of disease revealed, however, that a disruption in the blood-brain barrier allows blood proteins – and specifically fibrinogen – to seep into the brain. Microglia – immune cells that act as the brain’s first line of defense – initiate a rapid response to fibrinogen’s arrival. They release large amounts of chemically reactive molecules called ‘reactive oxygen species.’ This creates a toxic environment within the brain that damages nerve cells and eventually leads to the debilitating symptoms of MS. 

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