another MS breakthrough!

This is great news today :)

As we know, most of the medicine out there nowadays are so-called immunosuppressors – they “knock down” our immune response without selection leaving us highly susceptible to viruses and other infections.

What this new discovery aims at doing is targeting only the autoimmune response to myelin. And how is this done? “…intravenously with an infusion of (the patients. red) own white blood cells, which had been engineered to carry billions of myelin antigens.”

Researchers are hoping that the cells would teach the body to stop attacking myelin. Hope is last to die and remember, it is ‘just’ a breakthrough not a cure.. but we’re getting there!! :)
Read the full article here:

http://www.foxnews.com/health/2013/06/06/medical-breakthrough-for-multiple-sclerosis-sufferers/

/S

Microchip for us needle “lovers”… !

I just saw this and I personally believe it is great news.. considering that I’m such a needle “lover”…!!

The possibility of using microchips in the future to administer drugs might be a sign of relief for many MSers, among other sufferers…

We are talking about an implantable, wirelessly controlled and programmable microchip-based drug delivery device! It provides a real-time dose schedule tracking and remote control for physicians to adjust treatment schedules as necessary as well as complete automation.

It has been successfully tested on eight Danish women for the treatment of their severe osteoporosis. But the company claims that it could be used for the treatment of other chronic diseases that require treatment w. injections. More trials might and will be needed, and they expect to submit it for approval in 2014. It is expected to be available on the market in 5 years from now.

To read more about this amazing technological advance click on any of the links below:

http://www.reuters.com/article/2012/02/16/microchip-drug-idUSL2E8DG9F220120216

news_id=32618&news_channel_id=143&channel_id=143http://www.advisory.com/Daily-Briefing/2012/02/17/Microchip

http://newsfeedresearcher.com/data/articles_m8_2/drug-microchips-devices.html

http://chealth.canoe.ca/channel_health_news_details.asp?

:)

Stem cells & MS – Hope turns into reality..?

With all the talk about stem cell research in the field of MS I thought I’d write a little overview of what has happened so far…

The trial in stem cell transplant for MS happened in 1995. In 2003, the first positive trial with stem cell treatment was conducted on an MS patient in Sweden. The year after, in 2004, stem cell treatment was proclaimed to be just “very experimental”.

Only 3 years later, in 2007, did they realize that the use of stem cells could possibly play an important role for future MS treatments. And in 2009 a glimmer of hope was ignited. However, it remained still to early to be optimistic about stem cells and MS. There was a call for more controlled trials in 2010, to determine whether stem cells could be used as standard treatment for MS.

2011 was a turning point. Various researches claimed successful trials with stem cells on patients with MS.

This year (2012) a global research project is taking place, with the aim of analyzing and evaluating the possibilities of stem cell treatment for MS patients with mesenchymal stem cells (MSCs). MSCs are the primitive cells in the bone marrow.

What does the future hold for MS patients..? I believe hope might turn into reality – maybe stem cells are the answer we have all been waiting for.

If this year’s global research project proves to be successful, researchers say we might be looking at MSCs treatment becoming the standard treatment for MS in 2018.

I know that every research has its pros and cons. I also know that some reports have mentioned that patients who underwent stem cell treatment and were feeling “better than ever” unfortunately reverted back to their prior situation some months after the treatment.

I can just say we have to keep praying and hoping that they soon will find a cure no matter what it will be. Do not lose hope because some trials might not work out as you expect them to or because some people had relapses after all. Remember that we are all different and that it might work differently for you.

 

“We must accept finite disappointment, but never lose infinite hope.”

– Martin Luther King, Jr.

New MS therapies expected in 2012

Hi all,

I have just come across this interesting video where Dr. Ben Turner quickly highlights the key new MS therapies we can expect in 2012.

Among these you will hear a bit about Fingolimod (Gylenia), Teriflunomide (Aubagio), BG12 (Biogen’s nr. 12 drug) and Alemtuzumab (Lemtrada). He briefly introduces the drugs and gives a short explanation of the known benefits, supported by graphs.

To view the video click here: http://shift.ms/magazine/2012/02/new-therapies-what’s-around-the-corner-in-2012/

Never give up! =)

Cladribine – adios…

Unfortunately, today it was announced that Merck will no longer seek approval for the MS pill Cladribine due to the fact that regulators requested new clinical trials…

What does this mean? they won’t do the clinical trials required by the FDA & EMA as it will take them years before they finish these… but of course, we all know that this would imply a significant additional cost to the drug itself.

So what does this mean (besides the fact that we’re just money-making victims of a system selfishly and unfairly focused on the bottom line) ? Well, that we’re (unfortunately?) left with only one option for MS pill-treatment for the time being : Gilenya. And not only that, but apparently, this pill isn’t as efficient as ie. Tysabri, from what I heard from my doctors.

All those clinical trials gone to waste…? shame, we won’t have another pill option for the time being, but we can only hope that one day they decide to resume approval/trial and/or use their knowledge to develop an even better pill..;)

 

You can find the (more financial) report here on Bloomberg: http://www.bloomberg.com/news/2011-06-22/merck-kgaa-shares-slide-after-decision-not-to-seek-approval-for-ms-pill.html

Stem Cells hope for (aggressive) MS…

Ok..I know I haven’t been here for ages…and that this article is a bit “outdated” in the sense that it came out in March but I still consider it of high importance which is why I bring it up here.

The article published on March 23rd 2011 (Medical News Today -see link to the right) talked about how stem cells may help people with aggressive forms of MS by “replacing deliberately destroyed bone marrow with the patient’s own stem cells”.

What is basically done in this treatment is that the patient’s own stem cells are take out, then “cleaned” through a course of chemotherapy and placed back into the patient. These “purified stem cells are thought to “reboot” the immune system”!!

The results seen were really great and now further tests need to be done.

To read more please click here: http://www.medicalnewstoday.com/articles/219889.php

stay cool!

Ocrelizumab – reduces MS disease activity

As taken from the Medical News Today (Oct. 20.2010) website:

Ocrelizumab is an investigational humanized monoclonal antibody designed to selectively target CD20-positive B-cells, which are believed to play a critical role in multiple sclerosis (MS). It then interacts with the body’s immune system to eliminate CD20-positive B-cells.

Simply put, Ocrelizumab has demonstrated, through trials (they refer to phase II in particular), that there is a significant reduction in disease activity in patients with MS…as measured by brain lesions and relapse rate.

In fact, the reductions were impressive: the total reductions in the number of brain lesions detected by MRI scanning was 96% for 2000mg Ocrelizumab and 89% for 600mg Ocrelizumab (compared to placebo). Disease activity was also reduced significantly…

For more info on Ocrelizumab please visit the Medical News Today link (you can find under “links”).

Disease activity was also measured by reduction in annualized relapse rate (ARR), the rate of attacks or flare-ups per patient-year. At week 24, ARR was significantly lowered versus placebo with a reduction of 73% for ocrelizumab 2000mg and 80% for ocrelizumab 600mgii.

 

Previous Older Entries