EBV-specific adoptive immunotherapy

it feels like most of the time news are centred around discoveries that seem to be focused on the RRMS types… I have just read this article and it seems to shed light also for SPMSers too! :)

Based on the patient’s Epstein Barr Virus (EBV) researchers have managed to ” harvest some of [the patient’s] own T cells and grow them in the lab together with an EBV vaccine. Then, the boosted cells are transferred back to the patient intravenously.”

Of course, as always, further tests are required but the results seem to be promising and the test patient claims to have experienced a change for the better. Read more about the treatment (EBV-specific adoptive immunotherapy) and the test patient’s experience here: http://www.medicalnewstoday.com/articles/272326.php#rate



A future possibility to predict MS?

Wow… it has really been ages… I really do want to try to keep as updated as I can and follow on news but sometimes work and tiredness gets to you doesn’t it… ? it can be hard to manage :/

I guess it is the thought that counts, and the fact that after all I manage to squeeze in a few lines once in a while… So, today I read something interesting:). One day in the (hopefully near) future they might be able to test for MS long before disease onset.

To find out more about the research conducted on this molecular marker click here.

Enjoy your day!


another MS breakthrough!

This is great news today :)

As we know, most of the medicine out there nowadays are so-called immunosuppressors – they “knock down” our immune response without selection leaving us highly susceptible to viruses and other infections.

What this new discovery aims at doing is targeting only the autoimmune response to myelin. And how is this done? “…intravenously with an infusion of (the patients. red) own white blood cells, which had been engineered to carry billions of myelin antigens.”

Researchers are hoping that the cells would teach the body to stop attacking myelin. Hope is last to die and remember, it is ‘just’ a breakthrough not a cure.. but we’re getting there!! :)
Read the full article here:



Shrinkage of brain region may predict MS

This is an interesting discovery… how the thalamus could become a biomarker for MS because it’s detectable at a very early stage:




MS Disability linked to sodium buildup in brain

A recent article (Medical News Today) has suggested that a sodium buildup in the brain is related to disability in patients with MS.

The study found that for early-stage MS, specific brain regions were affected. However, for patients witha more advanced MS the accumulation was found throughout the whole brain.

Sodium buildup in motor areas of the brain correlated directly to the degree of disability seen in the advanced-stage patients“.

– a 3T sodium MRI scan can detect the sodium buildup in the brain:

Brain sodium MR imaging can help us to better understand the disease and to monitor the occurrence of neuronal injury in MS patients and possibly in patients with other brain disorders“.

Acrolein & MS

Purdue researchers have found evidence that an environmental pollutant may play an important role in causing MS and that a hypertension drug might be used to treat the disease. The research results represent the first concrete laboratory evidence for a link between acrolein and MS.

The compound is an environmental toxin found in air pollutants including tobacco smoke and auto exhaust. Acrolein also is produced within the body after nerve cells are damaged. Previous studies by the research team found that neuronal death caused by acrolein can be prevented by administering the drug hydralazine, an FDA-approved medication used to treat hypertension.

The new findings show that hydralazine also delays onset of MS in mice and reduces the severity of symptoms by neutralizing acrolein.

The researchers also learned the specific chemical signature of the drug that binds to acrolein and neutralizes it, potentially making it possible to create synthetic alternatives with reduced side effects. In MS, the myelin insulation surrounding nerve cells is destroyed and the nerve fibers themselves are damaged. Researchers of this study believe that acrolein is what degrades myelin and hope to be able to block that effect and thus delay the onset of MS and lessen the symptoms.

This is the first evidence that acrolein acts as a neurotoxin in MS and also the first time anyone has demonstrated hydralazine to be a neuroprotective drug. Other researchers had previously shown that acrolein damages liver cells and that the damage can be alleviated by hydralazine, leading the Purdue researchers to study its possible effects on spinal cord tissues.

< I’ve been absent for a while albeit following news… and made up my mind to post everything I had found interesting over the past months that I unfortunately didn’t have the time to post immediately…so please bear with me if some news aren’t “news” anymore… but I’ve simply decided to post them as I believe they are interesting to know… Therefore, for the full text visit Medical News Today (on the right) article dates back to November 24th 2010.. >

‘MS’ Blocked in Mice – new hopes raised..?!?!

Just a quick note.

I hope this one will reach you in good spirit and raise it even higher;)

It is an article published in Medical News Today, on March 8th that talks about an MS-like disease’s harmful cells being blocked in mice from entering the brain:


A good start…now we need more great results…and a real MS;)


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