Personal diary – MS Spasms abruptly disturb a quiet night’s sleep

hi, it has been a while.. and this is an unusual post from me… but… Im scared.. :/

I had a very strange and painful incident this Sunday. My whole body was spasming/twitching in the middle of the night (at about 3am). It lasted a good 20-30mins:( After I took some paracetamol and drank a bit it went away. The strange thing is that it was just like the flu like symptoms I had after my first interferon/avonex injection (as expected, being a side effect), but I haven’t had it since then..and that was ages ago (2005!)

And so yesterday my whole body was aching and even before I went to bed I could feel it in my arms and legs. Not the spasming, but more like pain in the muscles/joints. And every time when I got up to pee last night I had such difficulties walking because my right foot went completely numb! :(

I stayed at home today, couldn’t go to work :( Luckily I have a Tysabri appointment later this afternoon so I will talk to a doctor, see what he/she can tell me.

So what does my mind start wondering about..? I am thinking of death..is it nearby? Is it time? Just thoughts going through my mind..stupid thoughts. Will my boyfriend stay with me despite my potential disabilities? Although he really truly does love me, and I know that, can’t help but worrying on his behalf if he ends up with a challenged girlfriend…even though I know he knew from the beginning what MS could bring… silly huh? maybe you’ve had the same thoughts going through your head.. I just always think of the OTHER person, and how do OTHERS feel and how would this/that make THEM feel – it seems I always put others first rather than me, and my feelings and needs. I might need to work on that… but maybe it is just the way I am and I wont be able to do anything about it..

Just so you know, I have been on Tysabri since January 2009 (after Avonex failed on me following 4 years of weekly injections *chills*) and I have been very happy with it. I also have been confirmed, and re-confirmed that I (unfortunately) also carry the JC Virus.

Anyways, I am worried but I hope it is just a bad relapse… You are more than welcome to share your experiences with me, I’d be happy to hear from you!

Thanks! and stay positive;)
/S

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A future possibility to predict MS?

Wow… it has really been ages… I really do want to try to keep as updated as I can and follow on news but sometimes work and tiredness gets to you doesn’t it… ? it can be hard to manage :/

I guess it is the thought that counts, and the fact that after all I manage to squeeze in a few lines once in a while… So, today I read something interesting:). One day in the (hopefully near) future they might be able to test for MS long before disease onset.

To find out more about the research conducted on this molecular marker click here.

Enjoy your day!

/S

Key Biological Mechanism In MS possibly identified!

from the article, a very interesting discovery:

Fibrinogen, a blood protein that is involved in coagulation, is not found in the healthy brain. In vivo imaging over different stages of disease revealed, however, that a disruption in the blood-brain barrier allows blood proteins – and specifically fibrinogen – to seep into the brain. Microglia – immune cells that act as the brain’s first line of defense – initiate a rapid response to fibrinogen’s arrival. They release large amounts of chemically reactive molecules called ‘reactive oxygen species.’ This creates a toxic environment within the brain that damages nerve cells and eventually leads to the debilitating symptoms of MS. 

Link

And another new MS breakthrough!

Oregon Health & Sciences University (OHSU) were rejoiced by their new discovery which, as they claim, stands a good chance of helping people suffering from MS and a range of other neurological disorders.

The discovery centers around high levels of a particular enzyme not usually found in the brain, but only in those with brain damage due to MS, stroke and conditions.

It is believed if researchers can figure out how to block the enzyme, the brain can repair itself, where insulating shields around nerve cells have been damaged or destroyed (!!!).

“We have a chance now of understanding a whole new process that’s preventing repair of the brain.  And we have the possibility of finding a drug in the next several years that could repair the brain in MS patients and other patients where this nerve sheath is destroyed,” said Sherman (the Lead Researcher).

The next step is to find a drug or combination of medicines that block the enzyme.

Read the whole article here.

Univ. of Adelaide scientists have made MS progression breakthrough

Hi all!
I know it is a couple days old news but it is still great news even re-reading it today! so here it is:

UNIVERSITY of Adelaide scientists have revealed breakthrough research that has the potential to help prevent the progression of multiple sclerosis.

The researchers successfully halted the autoimmune disease in mice. This is the best news ever (for me:) 

MS was halted in mice – now all we have to do is test this on humans as well and hope for a major story changer!! :o) :o) :O)

Read more here:

Breakthrough in Adelaide 

and keep your heads up, there are lots of other news covering diverse research progresses it is amazing! 
HOPE IS LAST TO DIE!! :) :) :)

S

MS damage reversed in mice model of MS!!

This is just great news!!!

Science Daily published an article about the research that the Mayo Clinic has been doing with regards to reversing the damage that MS causes to the nerves (both regenerating and repairing them!!) – and the results seem promising!! :) :) :)

http://www.sciencedaily.com/releases/2012/06/120628131414.htm

we’re getting there…. :-)

Acrolein & MS

Purdue researchers have found evidence that an environmental pollutant may play an important role in causing MS and that a hypertension drug might be used to treat the disease. The research results represent the first concrete laboratory evidence for a link between acrolein and MS.

The compound is an environmental toxin found in air pollutants including tobacco smoke and auto exhaust. Acrolein also is produced within the body after nerve cells are damaged. Previous studies by the research team found that neuronal death caused by acrolein can be prevented by administering the drug hydralazine, an FDA-approved medication used to treat hypertension.

The new findings show that hydralazine also delays onset of MS in mice and reduces the severity of symptoms by neutralizing acrolein.

The researchers also learned the specific chemical signature of the drug that binds to acrolein and neutralizes it, potentially making it possible to create synthetic alternatives with reduced side effects. In MS, the myelin insulation surrounding nerve cells is destroyed and the nerve fibers themselves are damaged. Researchers of this study believe that acrolein is what degrades myelin and hope to be able to block that effect and thus delay the onset of MS and lessen the symptoms.

This is the first evidence that acrolein acts as a neurotoxin in MS and also the first time anyone has demonstrated hydralazine to be a neuroprotective drug. Other researchers had previously shown that acrolein damages liver cells and that the damage can be alleviated by hydralazine, leading the Purdue researchers to study its possible effects on spinal cord tissues.

< I’ve been absent for a while albeit following news… and made up my mind to post everything I had found interesting over the past months that I unfortunately didn’t have the time to post immediately…so please bear with me if some news aren’t “news” anymore… but I’ve simply decided to post them as I believe they are interesting to know… Therefore, for the full text visit Medical News Today (on the right) article dates back to November 24th 2010.. >